ABSTRACT
Relatamos o caso de um homem de 50 anos com uma rara associação entre moldes brônquicos e o uso de interferon peguilado e ribavirina. O paciente procurou o serviço de pneumologia por apresentar, há quatro meses, dispneia progressiva que evoluiu com tosse progressiva seguida da expulsão de moldes brônquicos frequentes e abundantes. O paciente foi tratado inicialmente com medicações broncodilatadoras e uso de corticoide oral e inalatório. Foram realizados fibrobroncoscopia, lavado broncoalveolar e análise do escarro, os quais não acrescentaram informações para elucidação diagnóstica. Durante o período sintomático, o paciente fez uso de interferon peguilado e ribavirina para o tratamento de hepatite C. Após 30 dias da interrupção das medicações, o paciente ficou assintomático. Este é o primeiro relato sobre a associação entre molde brônquico e o uso de interferon peguilado e ribavirina.
We report the case of a 50-year-old male patient with a rare profile: bronchial casts associated with the use of pegylated interferon and ribavirin. The patient sought treatment in a pulmonology clinic with a history of progressive dyspnea for four months that had evolved to progressive cough followed by frequent and abundant elimination of bronchial casts. The patient was initially treated with bronchodilators, as well as with oral and inhaled corticosteroids. Fiberoptic bronchoscopy, bronchoalveolar lavage and sputum analysis were carried out but did not contribute to the elucidation of the diagnosis. The symptoms developed while the patient was receiving pegylated interferon and ribavirin for the treatment of hepatitis C. The symptoms resolved 30 days after the discontinuation of the treatment. To our knowledge, this is the first report of bronchial casts caused by the use of pegylated interferon and ribavirin.
Subject(s)
Humans , Male , Middle Aged , Antiviral Agents/adverse effects , Bronchial Diseases/chemically induced , Calcinosis/chemically induced , Interferons/adverse effects , Ribavirin/adverse effects , Dyspnea/drug therapyABSTRACT
The effect of atorvastatin on warfarin-induced aortic medial calcification and systolic blood pressure (SBP) of rats induced by warfarin was studied. Thirty healthy and adult rats were randomly divided into Warfarin group (n=10), Atorvastatin group (n=10) and normal control group (n=10). Caudal arterial pressure of rats was measured once a week, and 4 weeks later, aorta was obtained. Elastic fiber, collagen fiber and calcium accumulation in tunica media of cells were measured by Von Kossa staining. The results showed that warfarin treatment led to elevation of systolic blood pressure and aortic medial calcification. The chronic treatment also increased collagen, but decreased elastin in the aorta. However, the atorvastatin treatment had adverse effects. It was concluded that treatment with atorvastatin presented evidence of blood pressure lowing and calcification reducing. These data demonstrate that atorvastatin protected aortic media from warfarin-induced calcification and elevation of systolic blood pressure.
Subject(s)
Aortic Diseases/chemically induced , Aortic Diseases/drug therapy , Aortic Diseases/pathology , Blood Pressure/drug effects , Calcinosis/chemically induced , Calcinosis/drug therapy , Calcinosis/pathology , Heptanoic Acids/pharmacology , Heptanoic Acids/therapeutic use , Hypertension/chemically induced , Hypertension/drug therapy , Pyrroles/pharmacology , Pyrroles/therapeutic use , Random Allocation , Rats, Wistar , WarfarinABSTRACT
Os autores relatam caso de epilepsia generalizada secundária ao depósito de cálcio putaminal em paciente de 33 anos de idade com hipoparatireoidismo conseqüente á tireoidectomia sofrida aos 15 anos. Discutem a descoberta näo fortuita de calcificaçöes intracerebrais na paciente, a necessidade de realizaçäo de tomografia computadorizada de crânio em todo o paciente epilético, além da iatrogenia medicamentosa anticomicial